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Supercritical CO2 Extraction of Auraptene from the Peels of Grapefruit


In this study, citrus oil was extracted from the peels of grapefruit by Supercritical (SC)-CO2, auraptene in the obtained extracts was separated by a silica gel column chromatography and thin layer chromatography (TLC), and then analyzed by using mass spectrometry (MS) and high performance liquid chromatography (HPLC). Results showed the extraction rate was high at high pressure and low temperature conditions. The maximal yield was about 60% at 25MPa, 328K, 2h and the CO2 flow rate of 2L/min.

Key words: grapefruit, peel, supercritical CO2 extraction, auraptene

Lian-die Zhuang, Da-peng Wu, Hong-tao Wang *,Yan-zhen Hong,Yu-zhong Su,Jun Li(Department of Chemical and Biochemical Engineering, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005)


Cancer has become a big killer endangering human health and life, and the treatment of cancer has become an urgent task. At present, other than paclitaxel, no other natural medicine has been found to have a significant therapeutic effect on cancer, which has caused great difficulties in the treatment of tumors. In recent years, foreign scientists have successively discovered an ether compound widely present in the peels and fruits of citrus plants-orange olein, which can effectively inhibit the formation of tumors in the skin, mouth, esophagus, colon and other parts of rodents. [1-5]. Therefore, the effective extraction and application of orange olein is of positive significance for cancer treatment.

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