supercritical co2 extraction machine
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Comparison of extraction technology of artemisinin by supercritical CO2 extraction equipment

The optimal parameters for the extraction of artemisinin from supercritical CO2 extraction equipment can be more than 95% pure:

Extraction pressure: 20 MPa

Extraction temperature: 333K

Extraction time: 2h

Summary

Artemisinin was extracted from Artemisia annua by supercritical CO2 extraction. The effects of extraction pressure, temperature and time on the yield of artemisinin were investigated. The results showed that the best extraction conditions were extraction pressure 20MPa, temperature 333k and extraction time 2H. The purity of artemisinin product was more than 95% after simple separation. Supercritical CO2 extraction process has many advantages, such as high selectivity, especially suitable for extraction of heat sensitive substances, simple separation process, energy saving, non-toxic, tasteless, pollution-free and residue free solvent CO2, which is very safe. However, due to high pressure requirements on equipment and small polarity of CO2, its extraction rate of macromolecular substances is low, which leads to extensive application in industry. Use is limited.

Extraction of artemisinin by supercritical CO2 extraction equipment
Extraction of artemisinin by supercritical CO2 extraction equipment

Supercritical CO2 Extraction Machine

Introduction

Artemisinin, also known as artemisinin, is a compound extracted and isolated from Artemisia annua L., an annual herb of Artemisia in the composite family. It was first isolated from Artemisia annua L. by Chinese scholars in the early 1970s. Artemisinin is the most effective drug for the treatment of cerebral malaria and chloroquine falciparum malaria in the world. The combination therapy has become the first choice of malaria treatment recommended by the World Health Organization. In addition to its antimalarial effect, artemisinin also has the effects of anti pregnancy, anti fibrosis, anti schistosomiasis, anti Toxoplasma, anti arrhythmia and tumor cytotoxicity, inhibiting scar fibroblasts, and anti herpes simplex virus. It is used in modern clinical treatment of falciparum malaria, fever, schistosomiasis, oral mucosa lichen planus, lupus erythematosus and arrhythmia. Artemisinin and its derivatives are new antimalarial drugs with high efficiency, high speed, low toxicity and safety.

 

Traditional extraction process of artemisinin

In the traditional process, artemisinin is completely extracted from plant Artemisia annua by using fat soluble organic solvent, and the extraction rate is nearly 100%. At the same time, the fat soluble impurities such as organic wax, volatile oil, artemisinin a, artemisinin B and artemisinin C are also extracted. Then high purity artemisinin was prepared by gradient elution of silica gel column chromatography with different polar eluents. A kind of

Supercritical CO2 Extraction Technology

supercritical CO2 fluid extraction machine
supercritical CO2 fluid extraction machine

Supercritical CO2 extraction (SFE) is a method of material separation by using the fluid with temperature and pressure higher than the critical point. In the supercritical state, the supercritical CO2 is contacted with the substance to be separated, so that the components with different polarity, molecular weight and boiling point can be extracted selectively. The dielectric constant and density of supercritical CO2 increase with the increase of the pressure of the closed system, and the components with different polarity can be separated and extracted by increasing the pressure of the program. Of course, it is impossible to obtain a single extract in each corresponding pressure range, so it is necessary to obtain the best mixing ratio through control conditions, and then change the CO2 gas from supercritical state to normal state by means of heating and reducing pressure, at this time, the extracted substance will automatically basically or completely separate out, so as to achieve the purpose of separation and purification.

Advantages of supercritical extraction of artemisinin

Extraction of artemisinin by supercritical CO2 extraction equipment
Extraction of artemisinin by supercritical CO2 extraction equipment

1. Supercritical CO2 fluid extraction is used. The temperature of extraction is low and inert gas is used to protect artemisinin from oxidation and destruction.

2. The combination of extraction and separation improves production efficiency and saves energy consumption.

3. In the process of extraction, the organic solvent in the traditional method is dispensed with, and there is no residual organic solvent in the finished product, which keeps the whole nature of the extract.

4. The whole process will not produce "three wastes" and will not cause pollution to the environment.

In conclusion

Artemisinin was extracted from Artemisia annua by supercritical CO2 extraction. The effects of extraction pressure, temperature and time on the yield of artemisinin were investigated. The results showed that the best extraction conditions were extraction pressure 20MPa, temperature 333k and extraction time 2H. The purity of artemisinin product was more than 95% after simple separation. Supercritical CO2 extraction process has many advantages, such as high selectivity, especially suitable for extraction of heat sensitive substances, simple separation process, energy saving, non-toxic, tasteless, pollution-free and residue free solvent CO2, which is very safe. However, due to high pressure requirements on equipment and small polarity of CO2, its extraction rate of macromolecular substances is low, which leads to extensive application in industry. Use is limited.

Free supercritical extraction test

China Jiangsu Nantong Huaan Supercritical CO2 Extraction System Co., Ltd has more than 40 years experience of supercritical fluid technology design andequipment manufacturing and it is the high tech company which is committed to the supercritical fluid technology development and supercritical CO2 fluid extraction equipment manufacturing. China a national torch project undertaking unit. Strict implementation of GMP standards, and has passed European CE standard certification, ISO 9001:2000 International Quality Management System Certification, ISO 14001 Environmental Certification and OHSAS 18001 Occupational Health and Safety Certification.

And we specifically supply for our customers custom laboratory, pilot and industrial scale super critical fluid intelligent extraction, dry, reaction, ultrafine grains and other equipment. Also we provide for the customers processing small experiment and cooperation to jointly develop services. Our company not only provides the super critical CO2 extraction distillation, concentration, purification, process technology and equipment of effective components from natural products but also provide the processing technology and equipment of the removal of residual solvent and pesticide residues in products.

Supercritical CO2 extraction of plant essential oils
Supercritical CO2 extraction of plant essential oils

You can send small samples to us and provide extraction requirements. We will help you with free testing in our lab.

supercritical co2 extraction equipment

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