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Supercritical co2 extraction process using entrainer

What is supercritical co2 extraction systems

  • Extension of supercritical carbon dioxide extraction technology

    Foreword:

    In order to further improve the extraction ability and selectivity of target solutes by CO2, researchers have studied various ways to expand the supercritical CO2 extraction technology, so that the application range of the supercritical extraction technology has been expanded.

  • Supercritical co2 extraction process using entrainer

    Abstract:

    However, the disadvantage is that the entrainer complicates the separation of the solute from the solvent and requires the addition of a special recovery system, such as the use of operation units such as evaporation and rectification.It is far less simple than using a single SCF process. The advantages and disadvantages of the method are determined.

  • Supercritical co2 extraction using an entrainer

  • Supercritical extraction of CO2 as a single medium

    Foreword:

    In SFE technology, supercritical CO2 extraction using CO2 as the extraction medium is the most widely used.

    Supercritical fluid extraction with CO2 as a single medium is mainly used for lipophilic, non-polar materials with small molecular weight, which is mentioned in the solubility rules and Compounds that are miscible or highly soluble with supercritical CO2. If the components contained in the raw materials belong to the mentioned compounds, it is difficult to extract and remain in the raffinate.

  • Solute solubility in supercritical CO2

    Foreword:

    It is of theoretical and practical significance to study the solubility of solutes in supercritical CO. The CO2 solubility rules summarized by the research results of francisah, Dandge, Hyat and other scholars are helpful for people to initially understand the solubility and selectivity of various solutes in supercritical CO2. The solubility rules are as follows:

  • The latest version of 2020 supercritical fluid extraction entrainer

    Description:

    In the supercritical state, CO2 has a selective dissolution. SFE-CO2 shows excellent solubility for low-molecular, low-polarity, lipophilic, low-boiling components such as volatile oils, hydrocarbons, esters, lactones, ethers, epoxy compounds, etc., like aroma components of natural plants and fruits.

    Learn more:What is supercritical co2 extraction systems

    For compounds with polar groups (-OH, -COOH, etc.), the more polar groups, the more difficult it is to extract, so the polyol, polyacid and polyhydroxy aromatic substances are difficult to dissolve in supercritical carbon dioxide. For compounds with high molecular weight, the higher the molecular weight, the more difficult it is to extract, and the polymer compounds with molecular weight exceeding 500 are also almost insoluble.

    For the supercritical fluid extraction of traditional Chinese medicine propolis for the active ingredients of Chinese herbal medicines with larger molecular weight and more polar groups, a third component needs to be added to the binary system composed of active ingredients and supercritical carbon dioxide to change the original effective The solubility of the components. In the research of supercritical liquid extraction, the third component with changing the solubility of the solute is usually referred to as the entrainer (there are also many literatures that refer to the entrainer as a subcritical component).

    Generally speaking, solvents with good dissolving properties are often good entraining agents, such as methanol, ethanol, acetone, and ethyl acetate.

  • Supercritical fluid extraction separation technology

    Description:

    Supercritical fluid extraction is a new type of extraction and separation technology.

    It uses a supercritical fluid, that is, a fluid in a thermodynamic state at a temperature higher than the critical temperature and a pressure higher than the critical pressure, as an extractant. Extract specific components from liquid or solid to achieve the purpose of separation.

    The characteristics of supercritical fluid extraction are: the extractant is a gas at normal pressure and room temperature, and it is easy to separate from the raffinate phase and the extraction group after extraction; it operates at a lower profitability, and is particularly suitable for the separation of natural substances; it can adjust the pressure , Temperature and attractive entraining agent can adjust the dissolving ability of the transboundary fluid, and can gradually extract the components into the desired product through the gradually density and temperature and pressure.

Abstract:

However, the disadvantage is that the entrainer complicates the separation of the solute from the solvent and requires the addition of a special recovery system, such as the use of operation units such as evaporation and rectification.It is far less simple than using a single SCF process. The advantages and disadvantages of the method are determined.

 General pilot scale supercritical co2 extraction process flow diagram, including CO2 pressurization system, CO2 circulation system, entrainer system, 2 extractors and 1 separator

Supercritical CO2 extraction of Rosemary essential oil
Supercritical co2 extraction of rosemary essential oil using an entrainer


It can be seen that in the research of supercritical CO2 extraction process using entrainer, the equipment required for supercritical fluid extraction with CO2 as a single medium and the process parameters required for research are necessary in supercritical extraction using entrainer The difference is that the device adds an entrainer addition system.When optimizing the operating parameters, it is necessary to consider the type, addition method, amount and speed of entrainer addition to the target substance extraction rate (or recovery rate) and selectivity influences.

Taking the extraction of effective components from andrographis paniculata as an example to illustrate the advantages of supercritical CO2 extraction using an entrainer. Studies have shown that andrographolide and dehydroandrographolide are the effective components in andrographolide, both of which are diterpene lactones. However, andrographolide and dehydrated andrographolide are unstable under heat and are easily damaged during the traditional alcohol extraction pharmaceutical process. At present, a new supercritical CO2 extraction process developed in China solves the problems of thermal decomposition and long production cycle of active ingredients during traditional process extraction and baking.

The following table compares the effects of different extraction methods on andrographis paniculata. Supercritical pure CO2 extraction has the lowest yield, only 1/10 of other extraction methods; when using 95% ethanol as an entrainer, operate according to optimized process conditions (extraction pressure 25MPa, extraction temperature 40 ° C, extraction time At 4h, the amount of entrainer is 1/2 of the raw material), the rate of extracting andrographolide (8.3%), the content of andrographolide (19.79%), and the content of dehydrated andrographolide (12.27%) are much higher than the traditional extraction. Method, and the product quality is stable and the drug effect is high, and all the indicators are better than the original solvent method. Although the ultrasonic ethanol extraction method and cold extraction with ethanol have better extraction results, the amount of solvent treatment is large and the solvent loss is large.

Extraction methodExtraction rate /%Andrographolide content /%Dehydrated andrographolide content /%
Cold ethanol6.1515.724.35
Ultrasonic ethanol extraction5.0510.173.43
SC-CO2(95%EtOH)8.3019.7912.27
SC-CO20.670.935.32

Effect of different extraction methods on andrographis paniculata 

The SCCO2 extraction process using entrainers can broaden the application range of supercritical extraction, especially when the extracted components have little solubility in supercritical solvents or require highly selective extraction. The SFE process using an entrainer not only improves the solvent's ability to extract solutes and reduces the amount of solvent required, but also greatly reduces the required pressure.

However, the disadvantage is that the entrainer complicates the separation of the solute from the solvent and requires the addition of a special recovery system, such as the use of operation units such as evaporation and rectification.It is far less simple than using a single SCF process. The advantages and disadvantages of the method are determined.

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