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Cold press CBD oil vs co2 extraction, who is better?

CO2 extraction process of cannabis oil

Is CO2 extraction better than cold press?

Quality cannabis extracts depend not only on the quality of the source flower but also on the extraction technique used. In this article, we'll cover how CO2 extraction and cold extraction work and the key factors that distinguish them.

How does CO2 extraction work?

Carbon dioxide extraction uses pressurized CO2 as a solvent to draw desirable compounds from cannabis, the actual process is relatively straightforward.

There are two basic steps in the CBD carbon dioxide extraction method.

First, the ground cannabis solids are placed in the extraction chamber. Pressurized carbon dioxide is pumped into the chamber where it dissolves the plant material and separates compounds such as cannabinoids.

In the second step, a pressure release valve facilitates the release of the material into a separate vessel, where heat and pressure encourage the cannabis compounds to separate from the carbon dioxide. The carbon dioxide is then exposed to a different temperature and pressure. This enables it to restabilize as gas and flow back into the CO2 tank, leaving behind amber-colored cannabis oil.

Cold press vs co2 extraction CBD

CO2 has been designated generally accepted as safe (GRAS) by the Food and Drug Administration (FDA).

Carbon dioxide is the most common compound used in high-pressure extraction. It boasts a number of benefits compared to other solvents used for botanical extraction.

For starters, carbon dioxide is a non-toxic substance that is readily available commercially for lower costs than other chemical alternatives. In addition, carbon dioxide is environmentally safe, and straightforward to work with, and it creates a superior product typically free of any by-products or residue. Modification of the temperature and pressure allows different cannabinoids, terpenes, and other compounds to be targeted, allowing the extraction process to be customized for different formulations. Most importantly, the nature of the CO2 extraction process itself tends to result in a superior product.

CO2 extraction vs cold press

Cold Press extraction is most commonly used in the production of essential oils, but some CBD brands tout it as their extraction method. The technique is typically reserved for fruits like citrus contained in the skin. Therefore, it cannot be used effectively to extract CBD from Cannabis. Any CBD brands that state they have used cold press are actually unlikely to have any CBD in their CBD Oils.

Cold press methods produce less total oil per batch than CO2 extraction.

CO2 extracts can vary – depending on the plant material and extraction conditions – between macerated extracts, pressed oils, or essential oils. Their high price is compensated for by the high quality, longer shelf life, and lower application dosage compared with conventional oils, extracts, or essential oils.

Further reading: Extraction Methods for Cannabidiol

What is Cannabidiol?

Cannabidiol, abbreviated as CBD, a type of cannabinoid, is the main chemical component in industrial cannabis, extracted from female cannabis plants.

CBD chemical formula
CBD and THC structure
cannabis co2 extract
cannabis co2 extract

Two attributes

  • The first feature of Cannabidiol is not addictive, and it has pharmacological effects such as antispasmodic, anti-anxiety, and anti-inflammatory.
  • The second characteristic is that it can also eliminate the hallucinogenic effects of tetrahydrocannabinol (THC) on the human body, known as anti-drug compounds.

These two attributes determine the CBD’s greatest value for industrial cannabis.

Chemical nature

The CBD was originally an organic compound isolated from Indian cannabis by Adams and Todd in 1940. In 1963 Mechoulam and Shvo measured their chemical structure. The chemical formula of CBD is C21H30O2 with a molecular weight of 314.46 Daltons.

From the structural point of view, CBD has optical activity and cis-trans isomers, and the natural CBDs are all left-handed trans-structures, namely (-)-trans-CBD.

Under normal temperature and pressure, the CBD is white or pale yellow resin or crystal, melting point 66-67 ° C, boiling point 463.9 ° C (760 mmHg), density 1.025 g / cm3, almost insoluble in water, soluble in organic solvents.

Because the chemical formula and molecular weight of CBD are completely consistent with THC, the physical and chemical properties of the two are very close, which leads to the difficulty in extracting CBD from industrial cannabis, which constitutes the technical barrier of the industry.

Extraction Methods

At present, the main methods for extracting active ingredients (usually organic compounds) from plants include steam distillation, pressing, and extraction.

Among them, the distillation method is suitable for substances with strong volatility, and the pressing method is suitable for the extraction of eschar materials that are liquid at normal temperatures. Since the CBD has a boiling point of more than 400 degrees at normal temperature and pressure and is insoluble in water, the extraction method is the most suitable extraction method.

After reviewing the current CBD extraction methods, we can summarize the CBD enrichment/extraction process into the following process, which is divided into four parts, including pre-treatment steps such as pulverization and drying, extraction steps, and concentration after extraction. A chromatographic purification step and a post-treatment step for the purified sample. Among them, extraction and purification are key steps.

  • Solvent extraction: The main advantages of the organic solvent extraction method are simple operation, low requirements on equipment, and low energy consumption. The disadvantages are that the organic solvent is liable to remain, the solvent dissolving ability is constant, and environmental pollution may occur.
  • CO2 extraction process: The main advantage of the supercritical carbon dioxide extraction method is that the separation range is wide, and the adjustment of the dissolution ability of the extractant can be achieved by changing the temperature and pressure, but the equipment requirements are high, the energy consumption is large, and the instrument cleaning is difficult.

At present, organic solvent extraction and supercritical carbon dioxide extraction are widely used, and subcritical water extraction is a new technology, which has not been used in the industrial production of CBD.

Organic solvent extraction

The organic solvent extraction method can also be divided into soaking extraction, reflux extraction, and ultrasonic extraction.

  • Soaking extraction: Soaking extraction is to directly extract and mix the organic solvent and the material for extraction, which takes a long time.
  • Reflux extraction: Reflux extraction is carried out by heating and distilling the leachate, distilling it and then condensing it, and then refluxing it back into the leather to continue the extraction process. Although the extraction efficiency is improved, continuous heating may cause the CBD. damage.
  • Ultrasonic extraction: Ultrasonic extraction is a method that uses ultrasonic mechanical effects, cavitation effects, and thermal effects to improve extraction efficiency. Ultrasonic extraction can be carried out at a lower temperature, and the extraction speed is fast, the efficiency is high, and the solvent usage is small, which has certain advantages over the former two.

CO2 extraction

The traditional carbon dioxide supercritical extraction uses pure carbon dioxide gas to reach a critical state under a certain temperature and pressure, showing the characteristics of the fluid and extracting the material.

However, in practice, in order to improve the extraction efficiency, a mixed CO-solvent, called an entertainer, is usually added to the superfluid, which is the main direction of the development of the supercritical extraction method.

How Processing Hemp Helps Improve CBD Extraction Rates

The first step in the CBD extraction process is the selection of raw materials.

The content of CBD in the raw material has a direct influence on the yield and purity of the final extraction. The higher the content of CBD in the raw material, the higher the yield and purity under the same process conditions.

Similar to THC, the content of CBD in various parts of cannabis is usually decreased in the order of bracts, flowers, leaves, stalks, and thick stems, and is highest in flowers and leaves of female flowers. Therefore, the processing of the CBD is usually carried out using the leaves.

In the treatment of raw materials, drying and comminution steps are usually included. The water in the raw material is reduced to 8% or even 5% by heating or drying. The meshing number is usually about 50-200 mesh to increase the contact area with the extraction reagent during the extraction process and improve the extraction efficiency.


There are also companies that use cellulase, pectinase or complex enzymes after drying and pulverizing to destroy the cell wall of cannabis to further improve extraction efficiency. However, the addition of enzymes also increases production costs. From the perspective of industrial production, the addition of enzymes may require comprehensive consideration.

CBD concentration and chromatographic purification

CBD concentration

The extracted extract is usually concentrated by heating before being purified by a chromatography column, the extraction solvent is evaporated and removed, and an extract composed of components such as CBD is left.

The effect of evaporation and concentration can remove some volatile impurities on the one hand, and replace the solvent with the mobile phase required for chromatography, on the other hand, facilitating chromatographic purification.

The steps of replacing the solvent are more flexible, and the changes are different in different technologies. In some techniques, the method of water sedimentation is used for concentration, and in some techniques, the organic solvent is used for multiple dissolution and concentration.

Chromatographic purification

The extract is dissolved in a solvent using a chromatographic mobile phase and then purified by a column. Purification of the column is carried out based on the difference in properties such as molecular weight and polarity of the different components.

Commonly used column packings include silica gel, macroporous adsorption resin, polyamide adsorption resin, etc., each of which can be subdivided according to chemical composition or crosslinking. Chromatographic elution solvents often use polar or non-polar organic solvents.

Different chromatography columns and different solvents can remove different impurities, and the recovery rates are not the same. In some technologies, a variety of chromatographic columns are combined to purify to improve the purity.

However, in the chromatographic process, the purity is usually not compatible with the recovery rate.

The selection of the column, the choice of the chromatographic solvent, and the choice of the chromatographic purification method need to be comprehensively considered.

Post-purification treatment

The chromatographically purified CBD solution also needs to be concentrated to remove the solvent to obtain a higher purity CBD oil or ester. The crystal of the CBD or the CBD sesame oil is then prepared by evaporation, drying, or supersaturation.