CO2 extraction process removes caffeine from green tea

The Ultimate Guide to Cosolvent in CO2 Extraction Processes

Co-solvent pump
Co-solvent pump

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Here we have compiled some articles about Supercritical Fluid (SCF) in the station, hope they can help you.

Role of cosolvents in CO2 extraction process

The role of the entrainer has two main points:

  • First, it can significantly increase the solubility of the separated components in supercritical fluids;
  • Secondly, the selectivity (or separation factor) of the solute can be significantly improved when an appropriate entrainer that plays a specific role with the solute is added.
CO2 extraction method of licorice

Type of co-solvents in CO2 extraction process


One type is miscible supercritical solvents, where the smaller content is considered as an entrainer.For example, the separation of heavy oils often uses two or more C3 ~ C3 light hydrocarbon mixtures.The synergy between the solvents makes the mixing Solvents are better than single solvents.

The other type is to add subcritical organic solvents to pure supercritical fluids. Depending on the amount of addition, they may form a single-phase miscible supercritical mixed fluid, or they may be entrained by the supercritical fluid. A mixed solvent of two phases, but the latter case is generally undesirable.

Two ways

Co-solvent can affect the solubility and selectivity of solutes in supercritical gases in two ways:

  • One is the density of the solvent;
  • The second is the interaction between solute and entrainer molecules.

In general, the addition of a small amount of entrainer has little effect on the density of the solvent gas, and the determining factor affecting solubility and selectivity is the Van der Waals force between the entrainer and the solute molecules or the specific intermolecular between the entrainer and solute Role, such as the formation of hydrogen bonds and other various chemical forces. In addition, after adding an entrainer, the critical point of the mixed solvent will change accordingly.

Some commonly used solvents are often used as co-solvent of CO2 for research. They can form a homogeneous miscible state with CO2 under moderate pressure and room temperature conditions.

For example, when polar solvents with high solubility parameters, such as methanol, ethanol, and acetone, are used as co-solvent and added to CO2, not only the continuous tunability of the fluid solubility parameter δ can be maintained, but also the δ value of the mixed fluid is improved; Because a special molecular force (such as Lewis acid-base force, hydrogen bonding force, association force, etc.) may be formed between the polar solute and the polar co-solvent, the solubility and selectivity of the solute are enhanced.

Simply the most complete
CO2 extraction process you can find

CO2 Extraction Process

From raw material preparation, we offer you the most complete CO2 essential oil extraction process.
At the same time, more than 100 CO2 essential oil extraction methods from the laboratory are also provided for you.


how to extract essential oils

Detailed explanation of CO2 extraction process steps of plant essential oils。

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how to extract cbd

About the co2 extraction machine cannabis.
You can read a lot of articles about cbd oil extraction from the Internet, but I can tell you for sure that they are not comprehensive at all, and even have wrong descriptions.

Let’s start reading

co2 extraction equipment
6l co2 extraction equipment

Use and selection criteria for entrainers in CO2 extraction process

There are two ways to add an entrainer:

  • The first is to directly add the entrainer to the raw material, and then pass the supercritical fluid (such as CO2) and maintain a certain contact time under constant temperature and pressure conditions, which is called the static method
  • The other is that the supercritical fluid and the entrainer are mixed by a high-pressure metering pump at a certain ratio and flow into the extraction device at a suitable flow rate to contact the raw materials.

Studies have shown that when the binding effect of the raw material matrix on the solute is the first influencing factor, the static method is effective. The infiltration of the raw material by the entrainer is beneficial to the release of the component to be extracted; and when the solubility of the component to be extracted in the supercritical fluid is The main influencing factor is that the continuous method of dynamic method will produce better extraction effect than the static method. The combination of the two is also common in the literature.

Why CO2 is used in supercritical fluid extraction
Why CO2 is used in supercritical fluid extraction

How to choose the co-solvent in CO2 extraction process

The selection of the co-solvent in CO2 extraction method should consider three aspects:

  • First, in the extraction section, the interaction between the entrainer and the solute is required to improve the solubility and selectivity of the solute;
  • Second, in the solvent separation section, the entrainer and the supercritical solvent should be able to be separated easily, and the entrainer and the target product should also be easily separated;
  • The third is to consider that the residue of the entrainer will not cause product pollution. The specific selection can refer to the selection method of the extractant during the solution extraction, or consider from the aspects of solubility parameters, Lewis acid-base dissociation constant, and changes in the absorption spectrum after the action of the entrainer with the solute


CO2 Extraction Machine Buyer’s Guide

As you can imagine, not all supercritical CO2 extractors are made the same.
For more than 30 years, we have customized many CO2 extraction machines (Tabletop CO2 Extractor) for many companies and university laboratories (1 lb CO2 extractor). Because each customer’s CO2 extraction process requirements are different, there are almost no identical machines.

How many liters of CO2 extraction vessels are needed?

The first factor that determines the size of the CO2 extraction vessel is the daily working hours of the plant, which determines the daily extraction batch. The vessel size of the CO2 extractor depends on the biomass to be processed per day.

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How many separators are needed?

How can I custom my separator when I need more terpenes in my How can I custom my separators when need more terpenes in CBD oil extraction process?
Waxes separation and Light oil separation in 1st separator;
Light oil separation in 2nd separator;
To trap lightest and volatile compounds in 3rd separator.
It is important to choose the right vessel size that will meet your current needs as well as future demand.

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How many pressure is best for your CO2 extraction process requirements?

The choice of CO2 extraction pressure is a changing factor. If the extraction pressure is too high, the useless substances in the plant will be extracted, such as wax and chlorophyll. If the extraction pressure is too low, the extraction time will be increased.

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How can the minimum operating costs be achieved?

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Further Reading: CBD Oil CO2 Extraction Machine