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Supercritical CO2 Extraction of Lithospermum Erythrorhizon

Lithospermum Erythrorhizon

Lithospermum (scientific name: Lithospermum erythrorhizon Zucc.) is a plant belonging to the Comfrey genus of the Boraginaceae. Perennial herb, the roots are rich in purple substances. Stems are usually 1-3, erect, 40-90 cm tall.

The leaves are sessile, ovate-lanceolate to broad-lanceolate, 3-8 cm long and 7-17 mm wide.

The inflorescence has stems and upper branches, 2-6 cm long, and the fruiting period is prolonged. The nutlets are ovoid, milky white or yellowish brown, about 3.5 mm long, smooth and shiny, and the midline of the ventral surface is concave with longitudinal grooves. Flower and fruit period is from June to September.

Distributed in North Korea, Japan, and China; in China distributed in Liaoning, Hebei, Shandong, Shanxi, Henan, Jiangxi, Hunan, Hubei, North Guangxi, Guizhou, Sichuan, Shaanxi, and Southeast Gansu. Grows on the hillside grassland.

Lithospermum perilla is used as a Chinese medicine with dried roots. It has the functions of cooling blood, activating serum, clearing heat and detoxification, and clearing skin rashes. It can treat heat spot rash, damp-heat yellow bile, vomiting blood, blood, blood in urine, diarrhea, bloody dysentery, heat constipation, burns, eczema, erysipelas, and other diseases.

Lithospermum Erythrorhizon Extract

Comfrey extract is an organic substance with the chemical formula C16H16O5, which is a purple flake crystal or crystalline powder. Insoluble in water, soluble in ethanol, organic solvents, and vegetable oils. It is easily soluble in alkaline water and precipitates out when it encounters acid. Used as a food coloring agent. Alkannin has anticancer activity, inhibits the cell cycle, and induces apoptosis. Alkannin ameliorates liver inflammation in the Rho kinase pathway.


Shikonin has anti-cancer, anti-inflammatory, antibacterial, and other effects. Clinically used for the treatment of acute and chronic hepatitis, liver cirrhosis (ascites). Dermohepatology is used to treat flat warts, and psoriasis and topical application to treat burns and promote wound healing. Eye drops are used for the treatment of herpes simplex virus keratitis, and have a certain effect on epithelial dendritic and superficial parenchymal dendritic keratitis. Oils are used to treat infant dermatitis, eczema, vaginitis, cervicitis, etc. Toothpaste containing shikonin can prevent dental caries and gingivitis. It can also be used as a coloring agent in medicine, cosmetics, and food.

Lithospermum Erythrorhizon CO2 Extraction Process

  • Pulverization degree:100 mesh
  • Extraction pressure: 14 MPa
  • Extraction temperature: 45°C
  • Separation pressure: 6 MPa
  • Separation temperature: 60°C
  • Extraction time: 100 min

Lithospermum root CO2 total extract

Lithospermum is a flowering plant that is native to Asia. The plant offers a rich, fascinating history. For over a thousand years, the dark red roots of Lithospermum have been cultivated in Japan and used for their extensive wellness and skincare applications. In the present day, Lithospermum Root Extract is gaining greater attention and is used in an array of luxe skin care products including creams, facial serums, cleansers, toners, and masks.

Lithospermum root CO2 total extract contains approximately 20% naphthoquinones, a group of organic compounds that is responsible for the dramatic red hue of the extract. These compounds offer impressive benefits within skin care applications. These naturally occurring components include shikonin, acetylshikonin, deoxyshikonin, isobuyrylshikonin, isovalerylshikonin, a-methylbutyrylshikonin B-hydroxyisovalerylshikonin and B,B-dimethylacrylshikonin.


Lithospermum root CO2 total extract may be used in a wide range of cosmetic, wellness, and other personal care formulations to incorporate the herbal benefits of the extract. We recommend doing several test batches to find the ideal usage rate for your product. The extract will impart a characteristic hue to your formulation and may limit your usage rate.

It may impart a blue-magenta hue in alkaline conditions.

While lithospermum root CO2 total extract may be used for its herbal benefits in personal care products such as creams, lotions, and balms, the FDA does not allow its intentional use as a color additive in such products. It may be used as a natural colorant in soaps as the FDA does not regulate the manufacturing or labeling of soap.


  • Dark Red Hue
  • Characteristic Bitter, Root-Like Aroma
  • Thick Liquid Consistency at Room Temperature
  • Standardized in Approximately 60% Organic Jojoba
  • Abundant in Naphthoquinones and Phytosterols
  • See Spec Sheet for Composition Data
  • Gromwell Root CO2 Total Extract is Well Suited for the Following Personal Care Applications:
  • Skin Care
  • Cosmetics
  • Soap Making
  • Recommended Usage:*
  • 0.03% to 0.1%